Étude et rapport

Antibodies to SARS-CoV-2 are associated with protection against reinfection

GRATUIT

Auteur(s) :

Sheila F Lumley, Denise O’Donnell, Nicole E Stoesser, Philippa C Matthews, Alison Howarth, Stephanie B Hatch, Brian D Marsden, Stuart Cox, Tim James, Fiona Warren, Liam J Peck, Thomas G Ritter, Zoe de Toledo, Laura Warren, David Axten, Richard J Cornall, E Yvonne Jones, David I Stuart, Gavin Screaton, Daniel Ebner, Sarah Hoosdally, Meera Chand, Oxford University Hospitals Staff Testing Group, Derrick W Crook, Anne-Marie O'Donnell, Christopher P Conlon, Koen B Pouwels, A Sarah Walker, Tim EA Peto, Susan Hopkins, Timothy M Walker, Katie Jeffery, David W Eyre

Éditeur(s) :

MEDRXIV

Date de publication :18/11/2020

30 pages

EN BREF ...

"SARS-CoV-2 infection produces detectable immune responses in most cases reported to date; however, it is uncertain whether previously infected people are protected from a second infection. Understanding whether post-infection immunity exists, how long it lasts, and the extent to which it may prevent, or reduce the severity of symptomatic reinfection, has major implications for the future of the SARS-CoV-2 pandemic and the corresponding global public health response. Post-infection immunity may be conferred by various humoral and cell-mediated immune responses. Key considerations when investigating post-infection immunity include identifying functional correlates of protection, identifying surrogate tests (usually antibody assays) as markers that may not be protective in themselves but act as a proxy for protection, and defining the end-points of interest e.g. prevention of reinfection, disease, hospitalisation, death or onward-transmission." En bref issu de l'étude.

Rédacteur(s) de la fiche : Beesens Teams


Introductio

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Conclusio

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